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KMID : 0363320050260020341
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Journal of Korean Oriental Internal Medicine
2005 Volume.26 No. 2 p.341 ~ p.352
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Treatment Effect of Jecksodoodangkuisan against Colonic Mucosal Ulcer Induced by Indomethacin in Mouse
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Choi Eun-Young
Hwang Tae-Hyun
An Joong-Hwan
Lee Seong-Hwan
Lim Seong-Woo
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Abstract
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Objectives: This study was carried out to investigate the effects of Jecksodoodangkuisan(JD) and Jecksodoodangkuisankahyunjicho(JH) against Colonic Mucosal Ulcer induced by indomethacin in mouse.
Methods: The normal group consisted of mice that were not inflammation-induced. The control group was untreated gastro-inflammation-elicited mice. The sample group mice were those administered BO, JD and JH after gastro-inflammation elicitation.
Results: In the immunohistochemical change, the distribution of COX-1 in mice treated with BO, JD and JH noticeably increased than control group(P<0.05). The distributions of NF-{kappa}B, p50, COX-2, ICAM-1, HSP70 and Substance P in mice treated with BO, JD and JH noticeably decreased more than control group(P<0.05). And JH was most effective treatment against Colonic Mucosal Ulcer in the immunohistochemical change.
Conclusions: According to the above results, Jecksodoodangkuisan and Jeckmdoodangkuisankahyunjicho are applicable treatments for Colonic Mucosal Ulcer.
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KEYWORD
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Jecksodoodangkuisan, Colonic Mucosal Ulcer, COX-1, NF-{kappa}B p50, COX-2
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